Abnormal megakaryocytopoiesis in the Belgrade laboratory rat
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Abnormal megakaryocytopoiesis in the Belgrade laboratory rat.
The Belgrade laboratory (b/b) rat has a hereditary hypochromic microcytic anemia because of defective transmembrane iron transport into erythroblasts. The present study was prompted by our previous work in which we showed that the b/b rat has hypomegakaryocytic thrombocytopenia associated with increased megakaryocyte size. To define the basic mechanism underlying this abnormality in the b/b rat...
متن کاملMegakaryocytopoiesis in the Rat
(With the technical assistance of Janet Donovan and Donald Howard) M EGAKARYOCYTES have been thought by some to make up a selfmaintaining compartment.1’2 Observations of labeling with tritiated thymidine ( H3TdR ), however, have indicated that morphologically recognizable megakaryocytes are not sell-perpetuating but are dependent on influx from precursor cells.8’4 In the present studies, megaka...
متن کاملPathophysiology of the Belgrade rat
The Belgrade rat is an animal model of divalent metal transporter 1 (DMT1) deficiency. This strain originates from an X-irradiation experiment first reported in 1966. Since then, the Belgrade rat's pathophysiology has helped to reveal the importance of iron balance and the role of DMT1. This review discusses our current understanding of iron transport homeostasis and summarizes molecular detail...
متن کاملIron metabolism in the Belgrade rat.
Iron metabolism in the Belgrade rat was examined in the intact animal and in the reticulocyte suspensions. The plasma iron turnover was increased. However, when allowance was made for the effect of the elevated plasma iron concentration, erythroid marrow capacity for iron uptake was at basal levels. Numbers of erythroid cells in marrow and spleen measured by the radioiron dilution technique wer...
متن کاملDefective delivery of iron to the developing red cell of the Belgrade laboratory rat.
Erythroid cell iron and transferrin uptake and release was studied in the anemia of the Belgrade laboratory rat (gene symbol, b), an autosomal recessive trait characterized by hypochromia and hyperferrinemia. When reticulocyte-rich red cells were incubated in vitro with doubly (59Fe, 125I) labeled transferrin, b/b cells demonstrated a significantly higher uptake of transferrin (164% of control ...
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ژورنال
عنوان ژورنال: Blood
سال: 1985
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v65.1.60.bloodjournal65160